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Applying SPR Imaging Technologies for Real-Time Monitoring of Cellular Dynamics and Drug Screening

Introduction Surface Plasmon Resonance Imaging (SPRI) has emerged as a pivotal label-free optical technique that enables real-time observation of biomolecular interactions and cellular dynamics. Unlike conventional fluorescence-based assays, SPRI relies on monitoring changes in the refractive index at a metal-dielectric interface—typically involving gold films—making it highly sensitive to surface-bound molecular events. This unique capability allows […]

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Microfluidic Platforms with SPR Sensors for Next-Generation Analytical Systems

Introduction The confluence of microfluidic technology and surface plasmon resonance (SPR) sensing represents a pivotal advancement in the evolution of miniaturized analytical systems. Historically, SPR sensors—while extremely sensitive to refractive index changes at the nanoscale—have been encumbered by operational limitations. These include reliance on manual sample delivery, low multiplexing throughput, and often bulky system architecture. […]