2-deoxy-D-glucose for covid a nobel discovery ?
The molecule 2-deoxy-D-glucose (2-DG) is not a novel molecule it was already existing for different purpose.
The drug has been developed by DRDO lab Institute of Nuclear Medicine & Allied Sciences in collaboration with Dr Reddy’s Laboratories. Clinical trial have shown that this molecule helps in faster recovery of hospitalized patients & reduces supplemental oxygen dependence: DRDO [ref]
What is 2-deoxy-D-glucose ?
The molecule 2-deoxy-D-glucose is not a novel molecule it's already existing for different purposes it was used as a diagnostic tool in pet scanning and also it has the potential use of using as an anti-cancer therapy. Clinical trials have shown to see it has any beneficial effect on symptomatic covid 19 patients.
2-deoxy-D-glucose has been approved by the drug controller general of India for use in symptomatic Covid 19 patients so this molecule generated a lot of interest. Now as you all know, Glucose is the most common source of cellular energy and a substrate for many biological processes because every cell in our body needs glucose. It is the universal feel for all of our cells. Since it's a hydrophilic molecule so it needs a transporter and the transporter for glucose is glucose transporters there are a variety of glucose transporters, we can say (for example) glucose transporter 1 to glucose transporter 14 . Property of the molecule :
| Empirical Formula (Hill Notation) | C6H12O5 |
| Molecular Weight | 164.16 |
Important points on 2-deoxy-D-glucose
Few of the notable results obtined at few specific studies have shown different results , here we have listed few of them in very brief. Please consult research papers toknow more if you need to know details about each. Few notable points include:
- 2-deoxyglucose can determine glucose metabolism, which is altered in diseases such as cardiovascular disease, tumors etc.
- It is an investigational drug that is being studied as an anti-cancer and antiviral agent.
- It was also used as an adjunct to chemotherapy and radiotherapy in the treatment of tumors
- 2-deoxyglucose was demonstrated to work as an anticonvulsant in temporal lobe epilepsy
- 2-deoxyglucose represses the expression of certain proteins that are at high levels after a seizure
Know more about the drug: [1]
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